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Ketoprofen, the active ingredient in Profenid-E, is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, pain-relieving, and fever-reducing effects. It works by:
- Inhibiting prostaglandin synthesis.
- Stabilizing lysosomal membranes (both in vitro and in vivo).
- Reducing leukotriene synthesis at high concentrations.
- Demonstrating anti-bradykinin activity (in vivo).
Ketoprofen's analgesic properties arise from its ability to inhibit prostaglandin production both centrally and peripherally. Its antipyretic effect may be due to suppressing prostaglandin synthesis in the CNS, particularly in the hypothalamus.
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✅ Description:
Profenid-E is recommended for managing conditions due to its anti-inflammatory, analgesic, and antipyretic properties. It is used for:
- Treating rheumatoid arthritis.
- Managing degenerative joint diseases.
- Addressing musculoskeletal and joint issues like tendinitis and sprains.
- Alleviating pain, such as dental pain, headaches, or primary dysmenorrhea.
Use medications as advised by a registered physician. - Ketoprofen is quickly and completely absorbed via the gastrointestinal tract.
- Approximately 99% of it binds to plasma proteins, primarily albumin.
- The elimination half-life ranges from 1.1 to 4 hours.
- The drug is primarily metabolized in the liver through glucuronidation and excreted via urine (50-90%) and feces (1-8%) within 1-5 days.
- Intramuscular administration results in peak levels of ~10 mg/L within 0.5 to 0.75 hours for a 100 mg dose, with a half-life of approximately 1.88 hours.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses:
- Pain relief
✔️ Dosage
Anti-inflammatory Dose:
- Starting dose: 150-300 mg/day, divided into three doses.
- Maintenance dose: Typically 100-200 mg/day, possibly reduced to twice daily or once daily.
- Maximum daily dose: 300 mg.
Pain and Dysmenorrhea:
- Usual dose: 25-50 mg every 6-8 hours as needed.
- Maximum daily dose: 300 mg.
Follow your doctor's instructions for the appropriate dosage.
✔️ Administration
Oral forms should be taken with fluids, preferably alongside food.
✔️ Possible adverse effects include:
- Common: Nausea, abdominal pain, vomiting, and dyspepsia.
- Rare: Vision issues, asthma, and blurred vision.
- Unknown frequency: Anaphylaxis, hypertension, kidney failure, or Stevens-Johnson syndrome.
✔️ Profenid-E 50: Not Recommended with Other Drugs:
- NSAIDs, including COX-2 inhibitors: Have a higher risk of gastrointestinal ulcers and bleeding.
- Anticoagulants, heparin, or drugs like warfarin, clopidogrel, and ticlopidine: Increased bleeding risk.
- Lithium: Possible elevation in plasma lithium levels.
✔️ Profenid-E 50: Drugs Requiring Caution:
- Potassium-altering medications (e.g., diuretics, ACE inhibitors): Risk of hyperkalemia.
- Corticosteroids: Higher likelihood of gastrointestinal bleeding.
- Diuretics: Potential renal failure, particularly in dehydrated patients.
- Methotrexate: Increased hematologic toxicity, especially at higher doses.
- Cyclosporin and tacrolimus: Higher nephrotoxicity risk.
✔️ Profenid-E should not be used in individuals with:
- History of allergic reactions (e.g., asthma) to ketoprofen or other NSAIDs.
- Severe heart failure or liver/kidney impairment.
- Peptic ulcers, gastrointestinal bleeding, or perforation history.
- Pregnant women in the third trimester.
✔️ Pregnancy & Lactation
- First and second trimester: Avoid use unless necessary, as safety is not established.
- Third trimester: Contraindicated.
- Nursing mothers: Not recommended.
✔️ Precautions
- Monitor renal and liver function, especially in patients with preexisting conditions or elderly individuals.
- Fluid retention and atrial fibrillation may occur.
- NSAIDs can mask signs of infection, such as fever.
✔️ Use in Special Populations
- Elderly: Start with a lower dose.
- Hepatic or renal impairment: Maintain minimal effective dosages.
✔️ Overdose Management
Symptoms of overdose (up to 2.5 g): Drowsiness, nausea, vomiting, or epigastric pain. Treatment involves gastric lavage and symptomatic care to address dehydration, urinary excretion, and acidosis. Hemodialysis may help in cases of renal failure.
✔️ Storage Instructions
Store below 30°C and away from light. Do not use after the expiration date. Keep out of reach of children. Dispense only under a registered physician's prescription.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
